Advanced SAM-e formula for dogs
Proven support for liver and cognitive functions while easing joint discomfort
SAM-e synthesis is a naturally occurring reaction within the livers and brains of dogs. While in the liver, it aids in the critical function of cleaning out the build-up of unwanted waste and may help repair cell damage. In the brain, SAM-e helps increase dopamine function, stimulates healthy cognitive function and works as an antioxidant.
Additionally, researchers have identified SAM-e as an effective anti-inflammatory that improves joint health. This means that pets that are already on maxxiSAMe, receive valuable joint support for minor everyday discomfort. However, if your dog has pre-existing joint problems and/or arthritis, they will still benefit from an additional joint supplement like maxxiflex+.
Patented stabilized powder works efficiently for the health of your dog
Our SAM-e formulation is specifically designed to protect the vulnerable SAMe nutrient from decreasing in potency.
Our fiber base protects against the acidity levels in dog’s stomach and allows for quick absorption into the intestinal track.
Our base also contains defatted flax, sunflower, and sesame seed fiber with naturally occurring immune and hormone boosting functions.
In addition to the intestinal support provided by the fiber, there are also the antioxidants provided by lignans, a group of chemical compounds found in plants that support immune systems and may help regulate hormone levels.
Boosted with additional valuable antioxidants and vitamins
We carefully formulated maxxiSAMe to provide serious support for ill or aging pets.
There are predictable deficiencies in nutrients that can further impact the overall health of the dog. Not only do our supporting ingredients in maxxiSAMe target liver health and cognitive function, but they also work throughout the body to prime it for the efficient processing of SAM-e.
maxxiSAMe has no artificial flavors, colors, preservatives, or binders.
To learn more about these hardworking supporting ingredients, including artichoke, B vitamins and lignans, and how they help your dog, go to the ingredients section below.
SAM-e for Liver Support
Learning the health of the dog you love is ailing is difficult. Liver issues often take a noticeable tole on the overall health and behavior of your pet.
Whether your dog is suffering from a chronic liver disease, a breed-specific liver ailment, or toxicities developed from the long-term use of non-steroidal anti-inflammatories (NSAIDS) or acetaminophen (Tylenol). maxxiSAMe can serve as an effective part of the care plan developed by your veterinarian.
S-adenosylmethionine (SAM-e), one of the active ingredients in maxxiSAMe, is proven to help prevent the build-up of unwanted materials in the liver so it functions efficiently. SAM-e supplementation helps protects the liver from further damage and may also help with cell repair.
SAM-e for Cognitive Support
As pets age, they too can be impacted by cognitive degeneration.
Cognitive Dysfunction Syndrome (CDS) is the result of age-related changes in the brain and can appear as confusion, memory loss and other symptoms of reduced mental function.
Unfortunately, cognitive dysfunction is incurable but early diagnosis and intervention can slow it down and improve your dogs' quality of life.
Working as an antioxidant, SAM-e helps increase dopamine function in the brain and is a safe and effective way to stall mental decline in aging pets.
Designed to be given easily with food
Our maxxiSAMe powder is designed to be mixed right in to your dog's food as part of their regular meals.
Other formulations of SAM-e for dogs may require a pill or chewable to be given one full hour before a meal on an empty stomach. No dog, or dog owner, enjoys that.
And our patented base containing additional vitamins and antioxidants, decreases the need for additional supplements related to your dog’s cognitive or liver health issues.
Easy to follow dosage instructions for dogs of any size
With maxxiSAMe just sprinkle the daily dosage over two meals a day, allowing for the maximum absorption of all ingredients.
Our powder formulation allows you to give the exact amount needed, making it easy to increase or decrease at the recommendation of your veterinarian.
Coated tablets containing SAM-e are sensitive to moisture and heat, and therefore cannot be split or crumbled without loosing the efficacy.
SAM-e is hard at work behind the scenes
While SAM-e is hard at work within your beloved pet’s liver and brain, expect marked improvements in attitude, energy, and the behavior of your dog.
As dogs grow older, they can face many of the same age-related health conditions as humans. They may begin to show signs of memory loss, forgetting a turn on your daily walk or struggling to find their favorite sleeping spot. Or you may notice changes in their appetite or behavior that helps your veterinarian diagnose a health issue with their liver. While these brain and liver health issues are very different, our maxxiSAMe addresses both.
Our unique stabilized SAMe (S-adenosylmethionine) powder boosts liver and cognitive functions while easing joint discomfort for ill or aging pets. At the same time safe and beneficial for dogs at any age. maxxiSAMe supports the internal strength of your dog where and when they need it most.
What is SAM-e?
SAM-e is a compound that is made naturally in the body and plays an important role in normal bodily function. The full name is S-adenosylmethionine but it is commonly referred to as SAM-e or SAMe.
SAM-e is formed from the essential amino acid methionine and adenosine triphosphate and is found in every living cell in the body. SAM-e, as it is within the cell, is the body's most important antioxidant but antioxidants are chemicals (natural and manmade) that can prevent or slow down cell damage.
There are no food sources of SAM-e but it can be given as a supplement. SAM-e has been used as human dietary supplement since 1999 in the US and for longer in many countries in Europe.
SAM-e is used to treat various conditions in humans, e.g. depression, anxiety, osteoarthritis, fibromyalgia, chronic fatigue syndrome (CFS), lower back pain, tendonitis, liver disease, dementia, and to slow down the aging progress.
"A sufficient number of clinical trials have supported the use of SAMe in disorders including depression, dementia, vacuolar myelopathy, and liver disease. Further studies should be performed, and it is of primary importance that the safety and tolerability of SAMe be assured. Reviews of clinical studies to date indicate that SAMe has a low incidence of side effects with an excellent record of tolerability" (The American Journal of Clinical Nutrition)
In recent years, SAM-e has been used for pets as well, and then mainly as liver supplement for dogs and cats. However, as with humans SAM-e can benefit pets in more ways.
maxxiSAMe is especially formulated by maxxipaws to address two common health issues in our pets, i.e. liver and brain (cognitive function) health.
How best to administer maxxiSAMe
One of the great benefits of maxxiSAMe is that it can be given with food (unlike coated tablets that must be given on empty stomach).
The easiest way to administer maxxiSAMe is therefore to mix it in with your dog's food. For maximum results, it is recommended to divide the daily dosage between two servings.
maxxiSAMe does not contain any artificial flavors, colors, preservatives, or binders, so it has natural flavor. The taste is mild (little sweet) to us humans and vast majority of pets happily eat their food when maxxiSAMe has been added to it.
However, if you experience any problems, please contact us and we will be happy to help.
Guaranteed quality ingredients & manufacturing
We never compromise on quality. maxxiSAMe is manufactured in USA, in GMP and NASC (National Animal Supplement Council) certified manufacturing facility.
All the ingredients used in maxxiSAMe are of pharmaceutical human grade quality. maxxiSAMe does not contain any artificial flavors, colors, preservatives, or binders.
That's not all... we guarantee that the stated ingredients are present in the product at the date of manufacturing.
The benefits of SAM-e for dogs
- Works to protect liver cells from damage while processing waste
- May help with the repair of already damaged cells
- Increases dopamine function in the brain (improves mood)
- Stimulates brain function and works as an antioxidant
- Effective anti-inflammatory to support joint health
Bonus benefits of SAM-e
SAM-e is not only good for liver and brain health. SAM-e is an effective anti-inflammatory. Multiple clinical trials involving thousands of people have shown SAM-e to improve joint health and help with the symptoms of osteoarthritis (Arthritis Foundation).
maxxiSAMe does not replace the need for dog joint supplements like maxxiflex+ for dogs with existing joint problems and arthritis. However, it provides valuable joint support to pets that require SAM-e supplementation.
The benefits of maxxiSAM-e over coated tablets
SAM-e powder formula has many benefits over coated SAM-e tablets:
Most dog owners have been there, trying to get their pet to eat coated tablets. Most dogs hate them so you either have to hide the tablet in a treat (and hope your clever pet will not manage to outsmart you and just eat the treat) or manually force it down your dogs throats, which let's face it, no dog owner enjoys doing and definitely not on a daily basis.
Coated tablets must be given on empty stomach because of the high acidity level in our dogs' stomach. This is to shield the tablet so it can make it to the intestine to be absorbed. As we have explained, the stabilized powder used in maxxiSAMe protects the SAM-e in the stomach and ensures it makes it to the intestine where it is absorbed.
With powder, you can simple mix it in with your dog's food. This is because maxxiSAMe, unlike coated tablets, can be given with food.
The fiber base used in maxxiSAMe powder makes absorption quicker and maximizes the availability of all of the ingredients in the intestinal tract.
What's more, including B vitamins in the formula increases the effectiveness of maxxiSAMe as it helps with the absorption of the SAM-e.
It is recommended to divide the daily SAM-e dosage between two servings for maximum results, i.e. to maximize the absorption of all ingredients. This is another thing you cannot do with coated SAM-e tablets.
Coated tablets are sensitive to moisture and extreme heat and can therefore not be split or crumbled.
Powder allows the pet owner to administer the exact dosage for pet of any size. maxxiSAMe is one product that fits dogs of all sizes, as well as cats.
This also makes it easier to increase or decrease the dosage if needed at the recommendation of your veterinarian.
What makes maxxiSAMe different
maxxiSAMe is maxxipaws proprietary SAM-e formula for pets, i.e. it is our own unique formula. The development aims were simple:
To develop effective premium quality SAM-e formula suitable for both dogs and cats
To effectively support canine and feline liver health and cognitive function
To make SAM-e formula for pets that is easy to administer
To make SAM-e formula that is suitable for pets of any size, i.e. one size fits all
We are proud to say that we achieved all our goals with maxxiSAMe advanced SAM-e formula for pets.
In its native form, SAM-e is labile (easily broken down) and degrades rapidly. SAM-e therefore has to be formulated in a way that protects it from the enzymes in the stomach.
The stomach acid in dogs and cats is lower than in humans but lower pH means higher acidity. Normal human pH is 1.5 – 3.5 on an empty stomach, pH 5 when it is full. While the pH in dogs and cats is between 1 and 2, or significantly more acid.
The SAM-e used in maxxiSAMe is patented stabilized powdered form of SAM-e. This protects the SAM-e from interaction with environmental factors, as well as from the other ingredients used in the formulation and guarantees the availability of the active substance (SAM-e) when taken orally.
What's more, this protects the SAM-e in the stomach and ensures it makes it to the intestine where it is absorbed.
Not just SAM-e
maxxiSAMe does not only contain SAM-e. It contains additional ingredients for extra potency. These ingredients (see details below) are specifically chosen as they also support good liver health and cognitive function in aging pets.
maxxiSAMe also contains all the necessary Vitamins B recommended for dogs with hepatobiliary diseases.This means you don’t have to buy or administer them separately.
B vitamins also support the body's absorption of SAM-e.
How SAM-e works for liver health
The liver produces SAM-e from the amino acid methionine. It is converted into glutathione which plays an important role in protecting the liver cells (hepatocytes) from damage from the waste products that the liver removes from the blood stream.
When the liver is damaged, then less SAM-e, and thus less glutathione, is produced. This means even more liver cells become damaged, i.e. vicious cycle has started.
SAM-e has been shown to increase the glutathione levels in dogs and cats.
How SAM-e works for cognitive function
SAM-e supplementation has been shown to be safe and effective way to stall or improve mental decline in aging pets.
SAM-e helps increase dopamine function in the brain, stimulates brain function and works as an antioxidant.
What is artichoke?
maxxiSAMe contains Cynara Scolymus, a.k.a. artichoke. It is a member of the milk thistle family and better known under its common name Globe Artichoke.
The artichoke's main plant contains a long list of constituents, including cynarin (the main constituent), silymarin and caffeic acid that have all been shown to be effective for liver health.
maxxiSAMe contains artichoke leaf extract 4:1 concentrate (which means that 4 kgs of starting material will result in 1 kg of extracted material when the starting material is extracted with a solvent).
This is concentrated plant material, not standardized extract. Meaning it contains a whole host of constituents, not just one.
So while Globe Artichoke contains silymarin it is just one of the constituent. Other ingredients, especially cynarin and caffeic acid are as important as silymarin for liver health.
The benefits of artichoke for dogs
- High in naturally occurring silymarin and cynarin
- Stimulates efficient production and processing of bile in the liver
- Supports the processing of the SAM-e
How it works
"Artichoke protects liver from poisonous effects of toxins in a manner similar to silymarin from milk thistle. It is able to prevent liver damage from the same wide range of poisons as milk thistle. Artichoke extract is also able to stimulate the regeneration of liver cells in much the same manner as does silymarin" (Rain-Tree).
One study found artichoke extract to demonstrate a significant antioxidant effect capable of protecting liver cells from damage. In addition, the artichoke extract hindered liver cancer in human liver cells. Another study found that artichoke leaf extract decreased fat and cholesterol levels in the liver. (Liver Support).
Artichoke stimulates the production of bile in the liver as well as the discharge of bile from the system. These two functions are very important to the liver’s well-being. As a natural diuretic and choleretic, artichokes stimulate bile production, improves gallbladder function and aid in a more efficient breakdown of foods for overall improved digestion (Underground Health Reporter).
What is choline bitartrate?
Choline is an essential micronutrient. It is vital for healthy liver function and normal brain development.
This is why maxxiSAMe contains choline bitartrate (40% choline cation).
The benefits of choline bitartrate
- Essential micronutrient for liver and brain function
- Works with Inositol to remove fat deposits from the liver
- Valuable in optimal brain development and cognitive function in aging pets
Animal studies have shown that choline is essential for optimal brain development and influences cognitive function in later life (Oregon State University).
How it works
Choline deficiency causes muscle damage and abnormal deposition of fat in the liver, which results in a condition called non-alcoholic fatty liver disease. Choline is therefore used for liver disease, including chronic hepatitis and cirrhosis.
Choline is also used for various human mental conditions, like depression, memory loss, Alzheimer's disease and dementia, Huntington's chorea, Tourette's disease, a brain disorder called cerebellar ataxia, certain types of seizures, and schizophrenia.
Dogs can also develop degenerative brain diseases, known as canine cognitive dysfunction syndrome (sometimes also called canine dementia).
What is inositol?
Inositol (sometimes called Vitamin B8) is one of the B complex vitamins (though not officially recognized as vitamin as it can be synthesized in the body from glucose).
Inositol is present in all body tissue but with the highest concentration in the brain, heart and eye lens.
The benefits of inositol for dogs
- Essential for the production and functioning of nerve cell communication
- Naturally calming effect for aging pets
- Works with choline to remove fat deposits from the liver
How it works
Inositol is involved in the production and action of neurotransmitters (chemicals that transmit messages between nerve cells). Inositol has been shown to have calming effect, hence one of the key ingredients in our maxxicalm calming aid for dogs. Inositol is used for many mental disorders, like depression, obsessive-compulsive disorder, and panic attacks.
Fear and anxiety is understandably among the symptoms of dog dementia. The calming effect of inositol can help aging pets to cope better with their declining mental state.
What's more, when choline and inositol are combined they work together to build the cell membranes. Both provide a lipotropic effect as result of their role in transporting fat from the liver, i.e. they act on fat metabolism by hastening removal, or decreasing the deposit, of fat in the liver.
What are B vitamins?
maxxiSAMe contains various B vitamins. All of the B Vitamins are essential for the liver to perform its multitude of metabolic functions.
Supplementation with B vitamins is generally recommended for dogs with hepatobiliary diseases (the hepatobiliary system refers to the liver, gall bladder and bile ducts, and how they work together to make bile).
maxxiSAMe contains the necessary vitamins B so you don’t have to buy or administer them separately. B vitamins also help with the absorption of SAM-e.
B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B complex vitamins, also help the body to use fats and protein.
B complex vitamins are needed for healthy skin, hair, eyes, and liver. They also help the nervous system to function properly (University of Maryland Medical Center).
The benefits of B vitamins for dogs
- Supports the processing and absorption of SAMe
- Essential for healthy metabolic functions
- Boosts cellular energy and red blood cell production
- Promotes efficient nerve function
- Recommended for all dogs with hepatobiliary diseases
Vitamin B5 (5 mg)
Vitamin B5 (D-Pantothenic Acid) is critical for the manufacturing of red blood cells.
It is also important in maintaining a healthy digestive tract and helps the body use other vitamins (not least Riboflavin).
Vitamin B1 (4 mg)
As well as supporting liver health and brain function, Thiamine (vitamin B1) may strengthen the immune system and improve the body's ability to withstand stressful conditions (being disorientated and confused is without a doubt very stressful for our dogs).
Vitamin B2 (4 mg)
Riboflavin (vitamin B2) works as an antioxidant by fighting damaging particles in the body known as free radicals. B2 is also needed to help the body change vitamin B6 into form it can use and is important for body growth and red blood cell production.
Vitamin B6 (4 mg)
Vitamin B6 (Pyridoxine Hydrochloride) helps the body to make several neurotransmitters, i.e. chemicals that carry signals from one nerve cell to another. It is therefore needed for normal brain development and function, and helps the body to make the hormones serotonin and norepinephrine, which influence mood, and melatonin, which helps regulate the body clock.
The body also needs Vitamin B6 in order to absorb vitamin B12 and to make red blood cells and cells of the immune system.
Vitamin B12 (5 mcg)
Vitamin B12 (Cyanocobalamin) is an especially important vitamin for maintaining healthy nerve cells, and it helps in the production of DNA and RNA, the body's genetic material.
What's more, Vitamin B12 and Vitamin B9 (folic acid) work together to produce S-adenosylmethionine (SAM-e), a compound involved in immune function and mood.
What is in the powder base?
The base in maxxiSAMe is not just a filling, it has its own health benefits for dogs. The base is therefore one of the ingredients in maxxiSAMe.
The base contains defatted flax, sunflower, and sesame seed fibre. This is a concentrated form of fiber supplying nearly double the lignan content from what is in whole flaxmeal.
Fiber for dogs
Fibre is important to cleanse the intestinal tract. It scrubs away debris and creates environment that allows the good bacteria to flourish (as fibre is the only food source for good bacteria, i.e. prebiotics). Without the flourishing good bacteria, the immune system and nutrient absorption suffers.
This means that maxxiSAMe can work faster than products that contain only actives. Actives that go into a sluggish inflamed intestinal tract can simply pass on by without being utilized.
The benefits of the powder base
- Naturally occurring hormone regulation and antioxidants
- Supports nutrient absorption
- Helps keep the intestinal track clear, allowing good bacteria to flourish
Lignans for dogs
Lignans are a group of chemical compounds found in plants. Lignans are high in antioxidants and fibre, and have anti-estrogenic effects, i.e. may help to regulate the hormone levels.
Lignans offers various health benefits for our dogs. Being high in antioxidants, they support the immunes system. While the hormone balancing properties of lignans means they are beneficial for both male and female animals that have been spayed or neutered.
Lignans has also been shown to be beneficial for Cushing's disease in dogs (overproduction of the stress hormone cortisol). Lignans inhibits HSD enzyme that may reduce the cortisol. For dogs' already suffering from Canine Cushing Disease, higher amount of lignans would though be required on a daily basis.
The bottom line is that lignans offers various health benefits for dogs of both sexes.